As a diagnostic application of the Kereos technology platform, the KER-0001 product uses both the ανβ3 integrin biomarker and Fluorine-19 imaging to detect the presence of angiogenesis. Angiogenesis is an important factor in the progression of cancer, cardiovascular disease and autoimmune disorders. The Kereos therapeutic products can also be imaged by MRI to confirm delivery of the therapeutic payload to the target, and assess clinical response.
In other words, the imaging characterisitics of the nanodroplet can be used to not only diagnose disease but it can also be used as a tool to assess the stage of the disease and the effectiveness of treatment. The figure below provides a three-dimensional view of a tumor and the tumor vasculature. The imgages allow for the monitoring of the progression of the vasculature and tumor size over time.